Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study

نویسندگان

  • Bok Ki Jung
  • Won Jai Lee
  • Eunhye Kang
  • Hyo Min Ahn
  • Yong Oock Kim
  • Dong Kyun Rah
  • Chae-Ok Yun
  • In Sik Yun
چکیده

BACKGROUND Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. METHODS Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. RESULTS Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. CONCLUSION Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.

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عنوان ژورنال:

دوره 18  شماره 

صفحات  -

تاریخ انتشار 2017